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Ayahuasca is a South American (pan-Amazonian) psychoactive brew used both socially and as ceremonial spiritual medicine among the indigenous peoples of the Amazon basin. It is growing in usage in Western society, including multiple Ayahuasca churches. It is a psychedelic and entheogenic mixed drink brew commonly made out of the Banisteriopsis caapi vine, the Psychotria viridis shrub or a substitute, and possibly other ingredients. Ayahuasca is a psychoactive brew that people make using the leaves of the Psychotria viridis plant and the stalks of the Banisteriopsis caapi vine. It may also contain other ingredients. The name “ayahuasca” originates from the Quechua language, where aya means soul or ancestors, and wasca (huasca) means vine or rope. Most people translate this as “vine of the soul.”

How does it work? 

Both plant ingredients in ayahuasca tea have hallucinogenic properties. The leaves of the P. viridis plant contain N,N-dimethyltryptamine (DMT), which is a strong psychedelic compound. The B. caapi vine contains MAO inhibitors (MAOIs) called beta-carbolines. MAOIs stop the body from breaking down DMT, which allows the psychedelic effects to materialize.

What are the health benefits?

Research indicates that ayahuasca may offer several potential health benefits, especially for brain health and emotional well-being. However, more studies are necessary to confirm these findings. Potential benefits include: 

Brain health

Both DMT and beta-carbolines, the main psychoactive ingredients in ayahuasca, may protect and restore parts of the brain. ResearchTrusted Source indicates that ingesting DMT can lead to a higher production of antistress and antioxidant proteins. The findings of a 2017 studyTrusted Source in mice suggest that harmine, the primary beta-carboline in ayahuasca, may have neuroprotective and cognitive-enhancing effects because it reduces inflammation and oxidative stress. However, there is a need for studies to confirm these results in humans.

Mindfulness

According to some studies, ayahuasca may increase a person’s ability to be in a mindful state. A small studyTrusted Source demonstrated that taking ayahuasca once a week for 4 weeks proved as effective as an 8 week mindfulness-based stress reduction (MBSR) course, in terms of increasing a person’s “acceptance.” In this case, acceptance refers to nonjudgmental attitudes and behaviors, which the researchers measured using a “mindfulness score.”

Mood and emotions

Ayahuasca may improve the regulation of mood and emotions, and it could also reduce stress and depression. According to one studyTrusted SourceB. caapi preparations demonstrate antidepressant activity, possibly due to the presence of harmine and other substances that contribute to neurogenesis. Neurogenesis is the production of neurons.

Post-traumatic stress disorder 

A 2018 research paperTrusted Source suggests that ayahuasca may be beneficial for people with PTSD. It helps with the retrieval of repressed memories, which paves the way for the brain to reprogram or extinguish the associated fear response. However, more research in this area is necessary to establish the safety and effectiveness of ayahuasca for people experiencing PTSD.

Risks and side effects

While some research highlights the potential benefits of ayahuasca, it is important to note that most of these studies were small scale, and some took place in animals or test tubes. 

Researchers also carefully prepare and control the brews of ayahuasca that they use, but this is not always the case outside of clinical trials.

There are some serious side effects of ayahuasca use, including death. People may experience temporary symptoms shortly after drinking the brew, including:

  • anxiety
  • diarrhea
  • nausea
  • panic
  • paranoia
  • vomiting

Ayahuasca can also interact with several medications, herbs, and medical conditions, and these effects can sometimes be severe. 

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N, N-Dimethyltryptamine is a chemical substance that occurs in many plants and animals and which is both a derivative and a structural analog of tryptamine. It can be consumed as a psychedelic drug and has historically been prepared by various cultures for ritual purposes as an entheogen.